Integrated forest management is faced with the challenge that the contribution of forests to economic and ecological planning targets must be assessed in a socio-ecological system context. This paper introduces a way to model spatio-temporal dynamics of biomass production at a regional scale in order to derive land use strategies that enhance biomass provision and avoid trade-offs for other ecosystem services. The software platform GISCAME was employed to bridge the gap between local land management decisions and regional planning by linking growth and yield models with an integrative mesoscale modeling and assessment approach. The model region is located in Saxony, Germany. Five scenarios were simulated, which aimed at testing different alternatives for adapted land use in the context of climate change and increasing biomass demand. The results showed, for example, that forest conversion towards climate-change-adapted forest types had positive effects on ecological integrity and landscape aesthetics. In contrast, negative impacts on landscape aesthetics must be expected if agricultural sites were converted into short rotation coppices. Uncertainties with stem from assumptions regarding growth and yield models were discussed. Future developmental steps which consider, for example, accessibility of the resources were identified.